Thrombocytopenia refers to a relatively reduced quantity of platelets in the blood. This condition leads to several minor traumas during normal functions like swallowing and chewing. The lesions may include petechiae, purpura, gingival bleeding and further also hemorrhagic bullae or hematoma. The decrease of the thrombocytes has wide variety of possible causes including different diseases, deficiencies and drugs. Therapeutic intervention depends on the etiology and severity of the condition.