Drug-antibody complexes depose in the tissue and cause complement activation and inflammation. It takes 1 to 3 weeks after drug intake/exposure. Nearly every drug or bacterial decomposition toxin may be a potential trigger. Fever, rash, swelling, lymphadenopathy, urticaria, vasculitis, arthralgias, serum sickness or glomerulonephritis are typical manifestations. An example of this is the fith disease (erythema infectiosum).